| 名稱 | STK11 p.KP178fs Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10465 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | STK11 p.KP178fs Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10465STK11 p.KP178fs Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10465 | |
| Gene | STK11 |
| Description | STK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603). |
| Technical Data | |
| DNA Change | c.532_536delAAGCC |
| AA Change | p.KP178fs |
| Mutation type | Frame_Shift_Del |
| Zygosity | Homozygous |
| Allelic Frequency | 100.00% |
| Transcript | ENST00000326873.7 |
| Cosmic ID | N/A |
| Chr position(GRCh37) | chr19:1220439_1220443 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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