| 名稱(chēng) | EGFR D770_N771insY/BaF3 |
| 型號(hào) | CBP73218 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | EGFR D770_N771insY/BaF3,母細(xì)胞：BaF3，EGFR D770_N771insY 導(dǎo)致在 Egfr 蛋白的蛋白激酶結(jié)構(gòu)域中氨基酸 770 和 771 之間插入酪氨酸 （Y） （UniProt.org）。 D770_N771insY 尚未進(jìn)行生化表征，但根據(jù)其他 Egfr 外顯子 20 插入。 |
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Email： zhangxiangwen@cobioer.com
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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73218EGFR D770_N771insY/BaF3
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| CBP73218 | |
| I. Introduction | |
Cell Line Name： | EGFR D770_N771insY/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
| III. Representative Data | |
1. WB of EGFR D770_N771insY/BaF3
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| 2. Anti-proliferation assay | |
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